The Minnesota Vikings lost their unbeaten record, falling 19-15 to the Detroit Lions. Jahmyr Gibbs ran for 153 yards and a touchdown for Detroit, which improved to 5-2.
Lions linebacker Jack Campbell was taken to hospital for treatment of a neck injury he suffered while tackling tight end TJ Hockenson in the fourth quarter.
Lamar Jackson injured his right thumb on the Baltimore Ravens' first snap of their game against the Buffalo Bills. Backup Tyler Huntley was then ruled out in the second quarter with a toe injury. Rookie Joe Fagnano finished at quarterback, and Buffalo won 36-10. The Ravens are 4-4 after losing their past three games. Jackson could miss the rest of the season, as he is set to undergo surgery.
The Denver Broncos beat the Kansas City Chiefs 28-24 after trailing by 11 points in the final quarter. Patrick Mahomes threw for three touchdowns and 321 yards for Kansas City. Denver's defense made a goal-line stop at the end of the game. The Broncos (6-2) moved ahead of the Chiefs (5-2) in the AFC West.
Joe Burrow threw for more than 450 yards, five touchdown passes and a rushing touchdown as the Cincinnati Bengals beat the Tennessee Titans 43-36 in overtime. The report says he was intercepted three times by Tennessee's Amani Hooker. The report also says Burrow is the first player in 75 years, and only the second ever, to record that combination in a single game.
The Dallas Cowboys lost 33-30 in overtime to the Arizona Cardinals, after Chad Ryland kicked a field goal. Gardner Minshew threw three fourth-quarter touchdown passes for Arizona after replacing Jacoby Brissett. Tyler Allgeier rushed for 147 yards for the Cardinals. Dallas is 3-5. Team owner Jerry Jones said of the loss: "It's an indictment of the whole show."